Comments
Transcript
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YWthank you for this.. just an observation,.. all those working on curing ageing (as a disease) all look...aged
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SBFantastic. Nice to see something non-financial for a change. Well done!
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IPI watched this 3 times, once every few days, because it is out of my field of anything I have ever read about, thanks so much really excellent
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SMThe idea of beling able to make a normal lifespan be largely free from disease and aging issues sounds like a huge positive, potential future. However, the idea of living longer concerns me greatly, because it could be argued that one way humanity evolves and improves is the people die. Can you imagine a world where the likes of Trump and many of the old white privileged GOP guys lived till 150 or 200 and kept control of society, I couldn't think of anything worse. I think we humans have a duty to do our time, if we can do that disease and issue free, fabulous, but we must know when its time to let go and let the next generations take over. Today we don't have that, and it has raised serious issues, so extending life I think will be disaster.
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TR...surprised to learn Justine's bio age is 10 years older (if true)...
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BYJust curious... are we still human if we cannot die..?
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IPhttp://www.monaottum.com/2017/01/10/sardinia-italy-home-of-the-healthiest-and-longest-living-men/
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JPI really enjoyed this video and hope to see more as the technology develops. I though maybe you'd interview Ned David of Unity Biotech which is the only publicly traded senolytic drug company. Their phase 1 results were mixed and illustrate the difficulty of applying treatments to humans (and investing in early stage biotech for that matter). In my opinion, longevity treatments among other health care is going to be the most interesting shift in spending over the next 50 years. Just as reduced costs in food and manufactured goods have led to people spending far less on them and more on travel, education, and homes, longevity will change everything. What's the price someone will pay for living longer? As much as they can afford, even if it's 80-90% of income.
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JCGreat documentary and fantastic to see Real Vision on top of the latest scientific developments. I have a good friend, Sergio Ruiz, who has been in the field for several years and often speaks on the subject, https://www.linkedin.com/in/sergio-ruiz/ RV should consider more interviews and more quality content on this subject!
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PJExcellent
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PGFascinating topic! Dave Asprey of Bulletproof coffee fame has spent years and hundreds of thousands of dollars in his "bio-hacking" quest...his latest book is on my list - Super Human: The Bulletproof Plan to Age Backwards and Maybe Even Live Forever! https://www.bulletproof.com/
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lcsurprised David Sinclair wasn't interviewed
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MHThis is the first RV doc my wife watched from start to finish. And yes I have been promoting quite a few others. Again: The first in all my years of membership. Well done! And yes: I also enjoyed it. Great info, very well presented. One doc at this level every month and I am happy.
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JHHurry up, please.
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MZAs usual, an extremely well produced and informative documentary from the brilliant Ms. Underhill. It must have been difficult to edit it down to just 26 minutes!...If there is a followup, it might be nice to profile some of the many companies that are working in the field of senolytics. Most of the ones that haven't been swallowed up by large biotechs are still private, but this is, after all, an investing network. Although any program about aging would be remiss not to include Mr. DeGrey, I think perhaps it should have been pointed out that he is an extremely controversial figure in the field. Also, there are many relatively simple and economical things one can do to extend their vital lifespan, for example, intermittent fasting. As with most things in life, the Pareto Principle applies. Finally, there are a number of websites where one can estimate their biological age without requiring medical tests - for example, RealAge.com. Give it a go, Justine: judging by your lovely and youthful appearance, you are exceedingly fit. Perhaps - as always in medicine - a "second opinion" is warranted!
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AMFor now fasting is the way to go for those who want to live healthier and longer. Dr. Valter Longo has good results. You need to fast 2x a year 5 days to kill off the bad cells. When you do that your organs are shrinking killing off the sick cells. When you start to eat you rebuild your organs back, most likely from stam cells. Have been doing it for 8 years now. Every year I take extended tests and so far results are very good. I do also 5:2 diet (don't eat 2 days, eat 5 days) just to be slim, also good for health but too short fasting to get rid of all the bad cells and re-generate. Artur, @Ar2go2
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JMVery interesting. Thanks! I wish us all an extra 10 years of healthy living.
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agJohn Mauldin was looking at this subject a while ago. Any chance he might be interviewed on this subject by RV ?
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JQWow Excellent Report! Please do more!
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TSWell done! Part of a puzzle? Anyone who has witnessed the tragedies of infants and young children in a cancer ward knows that biological aging fails causation tests here. Obviously simply increasing time presents greater risk opportunity (not necessarily a simple linear relationship, especially with environ and lifestyle change). Reducing or reversing biological aging remains a fascinating goal with much promise and moral dilemma. Who gets it? At what costs to society?
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WMGreat piece Justine and an huge potential disruptor for our aging society in terms of societal cost. For Real Vision Viewers interested in getting more information on aging / longevity and possible invest ideas read Juvenescence by Chalabi & Mellon.
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AMIn the metabolic theory of cancer, it’s shown that many cancers use sugar for fuel. I wonder if sugar too plays a negative role in this complex puzzle.
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DWThe subreddit \longevity covers this topic in great detail, mitochondria malfunction, nicotinamide riboside, mTOR inhibition, biohacking with metformin, etc. Check out the \fasting subreddit while you're there; intermittent fasting, Valter Longo's patented fast mimicking diet for immune system reset, many cases of Type 2 diabetes being cured by low carb diets, other fun stuff. Some micro and small cap investment opportunities but few firms making money yet. Stay lean, friends.
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TWExcellent episode! It increased my knowledge of aging mechanisms and their contributions to aging related illness. Thank you!
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BSJustine - Did Dr. de Grey or others discuss the use of the drug Rapamycin as an anti-aging protocol? There are doctors now who do so.
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MLGreat documentary. Might be also worth checking Kaya Kalpa and other Ayurvedic methods.
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DBWhat additional research, articles, etc are worth reading on the subject of aging? I am particularly interested in diet / fasting since drugs are as yet unavailable. Thanks RV and Justine!
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SSIts amazing, the effort, time and expense that goes in just making a 30 minute episode. Well done Justine and RV.
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DJFantastic documentary, and well covered
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PBFantastic work Justine!
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WBWhat a wonderful way to solve our health care problems and a big part of our debt issues!
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KDJustine, I am quite conversant with the literature in the anti-aging field and I would like to commend you on the terrific job that you did in your presentation.
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SSI conduct research in medical sciences and, in my opinion, this is an excellent piece, Justine. It presents some of the key aspects of longevity research: understanding the mechanisms underlying senescence promises to impact virtually all chronic diseases, shifting the foci of federal agencies (i.e., NIH) to fund these types of studies makes a lot of sense (some of that is going on currently and the NIA supports a large number of these studies), and efficacious therapeutic interventions are starting to arise which will offer many investment opportunities in the future (most of this is still quite far in the future). ...and to comment on the fasting discussion, yes, there is decent evidence for various types of fasting in humans to produce beneficial effects on metabolic function, systemic inflammation, and age-related biomarkers. Different fasting schemes (caloric restriction vs. short-term intermittent fasting vs. long-term fasting) appear to produce these effects through different mechanisms. Again, this work is in its infancy. Also, the DNA methylation profiling tests give you some idea about biological age, but they are far from perfect. DNA methylation patterns are tissue-specific. In a saliva sample, you're only interrogating methylation profiles of leukocytes and epithelial cells while ignoring all other cell types in your body. Keep up the great work, Justine.
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RPWow. Real Vision is growing up in front of our eyes. This is world class documentary content. I'm a rather proud father...!
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EBHas the age test you took been released to the public yet?
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DRWell done. Great documentary. Lots of stunning B-roll transitions. Thank you for this concise yet indepth discussion. Healthcare is so complicated i wonder who the winners and losers are in a macro view.
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AMExcellent work! And awesome news from the man with the impressive beard. Sex, drugs, and rock 'n roll in perpetuity sounds good to me.
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IOThis subject is very welcome. As said in the video we are at the cusp and there will be opportunities.
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SDGreat job Justine ! Incredible to think what the future might hold.
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RAExciting but R.I.P. social security. We will be so broke as a country