Episode 4: Some May Last Longer

Published on
November 1st, 2019
Duration
26 minutes

Episode 4: Some May Last Longer

Discoveries ·
Featuring Justine Underhill

Published on: November 1st, 2019 • Duration: 26 minutes

What kind of future are we building with the tools we have today? Within the medical community, a new way of thinking about human health is emerging. Instead of specific conditions and diseases being considered individually, aging is being considered as the primary cause for a host of ailments. In this episode, Justine goes on a journey to understand the longevity field, with the help of the scientists and doctors who are on the cutting edge. Justine visits the labs of Dr. Morgan Levine, Dr. Judith Campisi, Dr. Nathan LeBrasseur, Dr. Aubrey de Grey, and Dr. Vera Gorbunova, each of whom is researching a unique aspect of the aging puzzle. Filmed in 2019 in California, Connecticut, Minnesota and New York.

Comments

Transcript

  • SB
    Stewart B.
    19 November 2019 @ 19:37
    Fantastic. Nice to see something non-financial for a change. Well done!
  • ii
    ida i.
    15 November 2019 @ 07:51
    I watched this 3 times, once every few days, because it is out of my field of anything I have ever read about, thanks so much really excellent
  • SM
    Stephen M.
    1 November 2019 @ 16:21
    The idea of beling able to make a normal lifespan be largely free from disease and aging issues sounds like a huge positive, potential future. However, the idea of living longer concerns me greatly, because it could be argued that one way humanity evolves and improves is the people die. Can you imagine a world where the likes of Trump and many of the old white privileged GOP guys lived till 150 or 200 and kept control of society, I couldn't think of anything worse. I think we humans have a duty to do our time, if we can do that disease and issue free, fabulous, but we must know when its time to let go and let the next generations take over. Today we don't have that, and it has raised serious issues, so extending life I think will be disaster.
    • JU
      Justine U. | Real Vision
      1 November 2019 @ 20:35
      This is definitely a controversial issue, and one that came up many times as I was doing research. Leonard Hayflick mentioned it several times... something along the lines of what he said in this Nautilus article [1]: "By allowing asocial people, tyrants, dictators, mass murderers, and people who cause wars to have their longevity increased should be undesirable. Yet, that would be one outcome of being able to tamper with the aging process...My personal belief is that I would rather experience the aging process as it occurs and death when it occurs in order to avoid allowing the people who I just described to live longer." We have more than doubled our life expectancy in the past 300 years. Will extending life by another 20-30 years be an overall negative? At what number of years do we draw the line? There are a lot of tough questions this topic brings up. Either way, the research is going to continue to progress, whether it be in the U.S. or in China, Japan, Germany or elsewhere, so while the work on life-extension is unlikely to be arrested, it is worth considering the implications. [1] http://nautil.us/issue/42/fakes/ingenious-leonard-hayflick
    • SM
      Stephen M.
      1 November 2019 @ 23:12
      In reply to Justine, I understand the argument around longevity, but we are now getting into territory of extending life but only if you have the money. A direction of any kind aimed at longevity must be available to all and I think one of the major concerns going forward in many aspects of the world today is we have no clear directions or guidance on this. We have seen time and time again, that humans are not the greatest at self regulation, especially as we get higher up the socio-economic ladder. I fully get the idea of the potential benefits of allowing a life to be fully disease free and without issues, but to quote Billy Connelly (a UK comedian, getting close to the end and suffering with parkinson's disease), living longer would be fantastic if it was when you were 20 and you were partying, having fun and making love. Is it worth living another 50 years if you spend that time not being able to do the really fun stuff. A silly example I know, but it is an interesting point. Surely making life good for 80 to 90 years is good enough. Shouldn't we have a duty to allow younger people and generations to come through and live their own lives, which we are not allowing them to do at present. I'm not convinced around length of living, but as stated I see benefits of healthy current life span.
    • SJ
      Sean J.
      13 November 2019 @ 23:42
      "white privileged GOP guys"? How do I put a middle finger salute in here for this racist PoS? Note all your thumbs down, smart guy.
  • TR
    Tobias R.
    1 November 2019 @ 17:24
    ...surprised to learn Justine's bio age is 10 years older (if true)...
    • JU
      Justine U. | Real Vision
      1 November 2019 @ 20:08
      I was really surprised too! Especially given the fact that I exercise a lot and eat modestly. It could be due to my sweet tooth, or I could blame my parents-- as it seems we do inherit some epigenetic instructions [1]. Either way, as Steven S noted, different samples (saliva, blood etc) will give you a slightly different age reading. So I’m getting a blood test to check, and who knows—maybe I’ll need to make some significant lifestyle changes! [1] https://www.sciencedaily.com/releases/2017/07/170717100548.htm
    • SS
      Steven S.
      2 November 2019 @ 03:44
      Justine, although longevity isn't my research area, it hasn't been definitively shown that individual methylation profiles are highly correlated with healthspan. So, I wouldn't worry too much. If you want to be comprehensive, then not only blood DNA methylation profiling could be useful, but other complementary assays such as telomerase activity, telomere length, insulin growth factor, some interleukins, dehydroepiandrosterone sulfate, etc. would provide a fuller picture of your biological age (along with saliva DNA methylation). And something as mundane as family history might trump them all. This becomes quite the rabbit hole. Also, not much is known about the role of other epigenetic mechanisms, such as histone acetylation, in aging. Perhaps your saliva methylation patterns indicate an older age, but your histone acetylation and IGF levels argue for a 24 year-old age. So, fret not and keep exercising and eating modestly as they will undoubtedly serve you well. ...at least much better than my steady diet of bourbon and copious quantities of bacon. Bringing it back to finance, this area could be an incredible for future investments. A number of the anti-senescence and senolytic compounds have many of the hallmarks of future blockbusters in this capacity. The downsides are lack of IP protection on many of them and uncertainty of how to commercialize in our current healthcare system. ABT-263, mTOR inhibitors (e.g., rapamycin), metformin, pterostilbene, UBX0101, UBX1967, and nicotinamide riboside are all quite interesting.
    • JU
      Justine U. | Real Vision
      2 November 2019 @ 16:45
      Wow, thank you for your note Steven. I don’t want to say too much (I just want you to write more comments!), but I did want to give a little bit of a background on one of the drugs you mentioned. Metformin is one of the most popular treatments to control blood sugar in type 2 diabetes. But in recent years, metformin has demonstrated effectiveness way beyond diabetes. A 2014 UK study initially set out to measure the effectiveness of metformin versus another first-line diabetes drug. The researchers used a data set from NHS to look at the survival rates of around 78,000 diabetics being treated with metformin, 12,000 diabetics on the other drug, and 90,500 carefully matched controls without diabetes [1]. To their surprise, they discovered that not only did the diabetics on metformin have a far higher chance of survival than those on the other drug, but they also did significantly better than the non-diabetic controls, suggesting that metformin had a general protective effect against aging. There is still a lot to learn about metformin's mechanisms of action, but researchers believe a key role is to enhance the activity of an enzyme within cells that inhibits the process of burning glucose for energy – thereby mimicking the effects of calorie restriction. There is currently a landmark study on metformin (called TAME, or Targeting Aging with Metformin), with a goal of getting the FDA to accept a drug that targets mechanisms of aging. Right now the FDA only approves drugs for specific diseases, and they don’t recognize aging as a medical condition. [2, 3] So in a way, this study is a precedent-setting test case—one that could change the rules going forward. [1] https://www.ncbi.nlm.nih.gov/pubmed/25041462 [2] https://www.wired.com/story/this-pill-promises-to-extend-life-for-a-nickel-a-pop/ [3] https://www.fightaging.org/archives/2019/09/tame-trial-for-the-effects-of-metformin-in-humans-to-proceed-this-year/
    • PP
      Peter P.
      2 November 2019 @ 22:35
      I really was not surprised. I think in the video she said she was 30. She looks more like 40 than 30 to me. My wife is 50 and looks younger than her honestly. One has to be careful though with these types of tests. How do we know its really accurate? Justine looked like she was going to cry when she found out her test results. This can be very stressful to some people, and honestly end up causing more harm than good from the additional stress it adds to their life. The ONLY proven method to slow aging is calorie restriction. Everything is is just theories and ideas, all unproven. Restricting your calories by 30% is not real appealing to most people long-term.
    • RO
      Robert O.
      3 November 2019 @ 04:21
      It seems that if the test Justine took to estimate her physiologic age was truly valid, you would think that every major life insurance company would be using it to set their rates. I suspect that this test like so many secondary markers that have been tried in the past will be found wanting. As an example look up the CAST trial, which decreased premature beats following a myocardial infarction, which was thought to be a good thing until they found out that the treatment arm did worse than the placebo. Has anyone tried to develop a database on highly functioning 90 year olds to try to determine some common biological advantage that they might have?
    • ii
      ida i.
      4 November 2019 @ 10:08
      Yes you look 20! ... I have noticed a big problem in many countries. I live in Italy and grew up in Canada, and when I go abroad, I am shocked about how fatty the food is pretty much anywhere, the ice cream is sweeter, drinks are sweeter, tomato sauce has suger added! for example, in Italy I usually eat a pasta or rice dish at lunch without meat, I never add sugar to anything, and in the evening I eat some form of protean (beans, fish, meat once in a while, parmigiano cheese), no dressing or mayo etc., and I find it very very hard to keep this style of eating abroad. in North America, you ask for a small portion and you always get huge portions; eating a light pasta dish with fresh tomato or fresh vegetables without suger anywhere is difficult even if you are willing to pay. I think this is a key factor in general.
    • WM
      Will M.
      10 November 2019 @ 16:42
      Greg T. Surprised you are still married with your tendency for needless negative personal commentary....
  • BY
    Bowie Y.
    8 November 2019 @ 15:00
    Just curious... are we still human if we cannot die..?
  • ii
    ida i.
    6 November 2019 @ 21:52
    http://www.monaottum.com/2017/01/10/sardinia-italy-home-of-the-healthiest-and-longest-living-men/
  • JP
    John P.
    6 November 2019 @ 19:28
    I really enjoyed this video and hope to see more as the technology develops. I though maybe you'd interview Ned David of Unity Biotech which is the only publicly traded senolytic drug company. Their phase 1 results were mixed and illustrate the difficulty of applying treatments to humans (and investing in early stage biotech for that matter). In my opinion, longevity treatments among other health care is going to be the most interesting shift in spending over the next 50 years. Just as reduced costs in food and manufactured goods have led to people spending far less on them and more on travel, education, and homes, longevity will change everything. What's the price someone will pay for living longer? As much as they can afford, even if it's 80-90% of income.
  • JC
    Jerry C.
    5 November 2019 @ 20:19
    Great documentary and fantastic to see Real Vision on top of the latest scientific developments. I have a good friend, Sergio Ruiz, who has been in the field for several years and often speaks on the subject, https://www.linkedin.com/in/sergio-ruiz/ RV should consider more interviews and more quality content on this subject!
  • PJ
    Peter J.
    5 November 2019 @ 09:21
    Excellent
  • PG
    Philippe G.
    3 November 2019 @ 23:19
    Fascinating topic! Dave Asprey of Bulletproof coffee fame has spent years and hundreds of thousands of dollars in his "bio-hacking" quest...his latest book is on my list - Super Human: The Bulletproof Plan to Age Backwards and Maybe Even Live Forever! https://www.bulletproof.com/
    • RS
      R S.
      4 November 2019 @ 04:42
      Spam
    • PG
      Philippe G.
      4 November 2019 @ 23:52
      Yeah, no...not spam.
  • lc
    ludovic c.
    2 November 2019 @ 08:50
    surprised David Sinclair wasn't interviewed
    • JU
      Justine U. | Real Vision
      2 November 2019 @ 16:33
      This topic is huge (even though the amount of research is fairly small compared to cancer and other age-related diseases). Dr. Sinclair has done a lot of really interesting research, as has Dr. Nir Barzilai and Dr. Juan Carlos Izpisua Belmonte (I highly recommend checking out their work). If we do a follow-up video on this topic, those would be the people at the top of my list (covering the topics of stem cell research, Yamanaka factors, metformin, mTOR inhibitors and fasting). It was definitely difficult to pare it down for this video!
    • lc
      ludovic c.
      4 November 2019 @ 21:03
      Thank you for the update!
  • MH
    Marco H.
    4 November 2019 @ 18:58
    This is the first RV doc my wife watched from start to finish. And yes I have been promoting quite a few others. Again: The first in all my years of membership. Well done! And yes: I also enjoyed it. Great info, very well presented. One doc at this level every month and I am happy.
  • JH
    Joseph H.
    4 November 2019 @ 18:14
    Hurry up, please.
  • MZ
    Martin Z.
    4 November 2019 @ 08:15
    As usual, an extremely well produced and informative documentary from the brilliant Ms. Underhill. It must have been difficult to edit it down to just 26 minutes!...If there is a followup, it might be nice to profile some of the many companies that are working in the field of senolytics. Most of the ones that haven't been swallowed up by large biotechs are still private, but this is, after all, an investing network. Although any program about aging would be remiss not to include Mr. DeGrey, I think perhaps it should have been pointed out that he is an extremely controversial figure in the field. Also, there are many relatively simple and economical things one can do to extend their vital lifespan, for example, intermittent fasting. As with most things in life, the Pareto Principle applies. Finally, there are a number of websites where one can estimate their biological age without requiring medical tests - for example, RealAge.com. Give it a go, Justine: judging by your lovely and youthful appearance, you are exceedingly fit. Perhaps - as always in medicine - a "second opinion" is warranted!
    • KS
      Kathleen S.
      4 November 2019 @ 13:57
      Totally agree --- I have studied fasting and it is one of the most powerful ways you can dramatically improve your health. Our bodies are not designed to be eating 18 hours a day.
  • AM
    Artur M.
    1 November 2019 @ 07:53
    For now fasting is the way to go for those who want to live healthier and longer. Dr. Valter Longo has good results. You need to fast 2x a year 5 days to kill off the bad cells. When you do that your organs are shrinking killing off the sick cells. When you start to eat you rebuild your organs back, most likely from stam cells. Have been doing it for 8 years now. Every year I take extended tests and so far results are very good. I do also 5:2 diet (don't eat 2 days, eat 5 days) just to be slim, also good for health but too short fasting to get rid of all the bad cells and re-generate. Artur, @Ar2go2
    • DW
      Daniel W.
      1 November 2019 @ 10:09
      Is there any scuentific proof for this theory?
    • RA
      Ralph A.
      1 November 2019 @ 11:44
      I fast 5 times a week for like 20 hours, basically just eat dinner. I have been doing this for 7 years and I look way younger than my siblings (I’m the middle child)
    • TJ
      Terry J.
      1 November 2019 @ 18:40
      I could not agree more Artur. Lots of research shows this to be so, in addition to eliminating sugar and processed foods. Daniel, Dr Mercola's website would be good starting point for you. Good luck!
    • RS
      R S.
      4 November 2019 @ 04:57
      There is plenty of evidence for the benefits of infrequent, multi-day fasts. Essentially there are no downsides, and plenty of benefits, so it's one of the better practices you can adopt. Of course, it's better if you eat less processed food period, but adding a few fasts to your year will also help.
  • JM
    Jeff M.
    4 November 2019 @ 04:24
    Very interesting. Thanks! I wish us all an extra 10 years of healthy living.
  • ag
    anthony g.
    3 November 2019 @ 22:11
    John Mauldin was looking at this subject a while ago. Any chance he might be interviewed on this subject by RV ?
    • TS
      Tom S.
      4 November 2019 @ 03:04
      Mauldin associate Patrick Cox has been pounding the table on the subject for a quite a few years ...
  • JQ
    Joseph Q.
    4 November 2019 @ 02:27
    Wow Excellent Report! Please do more!
  • TS
    Tom S.
    4 November 2019 @ 01:10
    Well done! Part of a puzzle? Anyone who has witnessed the tragedies of infants and young children in a cancer ward knows that biological aging fails causation tests here. Obviously simply increasing time presents greater risk opportunity (not necessarily a simple linear relationship, especially with environ and lifestyle change). Reducing or reversing biological aging remains a fascinating goal with much promise and moral dilemma. Who gets it? At what costs to society?
  • WM
    Will M.
    2 November 2019 @ 16:30
    Great piece Justine and an huge potential disruptor for our aging society in terms of societal cost. For Real Vision Viewers interested in getting more information on aging / longevity and possible invest ideas read Juvenescence by Chalabi & Mellon.
    • WM
      Will M.
      2 November 2019 @ 16:31
      ....and who on earth downvotes this video.......!!!!!!
    • ag
      anthony g.
      3 November 2019 @ 21:16
      this is a great read on this subject.
  • AM
    Andrew M.
    3 November 2019 @ 15:33
    In the metabolic theory of cancer, it’s shown that many cancers use sugar for fuel. I wonder if sugar too plays a negative role in this complex puzzle.
  • DW
    Dean W.
    3 November 2019 @ 00:20
    The subreddit \longevity covers this topic in great detail, mitochondria malfunction, nicotinamide riboside, mTOR inhibition, biohacking with metformin, etc. Check out the \fasting subreddit while you're there; intermittent fasting, Valter Longo's patented fast mimicking diet for immune system reset, many cases of Type 2 diabetes being cured by low carb diets, other fun stuff. Some micro and small cap investment opportunities but few firms making money yet. Stay lean, friends.
  • TW
    Tom W.
    2 November 2019 @ 23:53
    Excellent episode! It increased my knowledge of aging mechanisms and their contributions to aging related illness. Thank you!
  • BS
    Bernie S.
    1 November 2019 @ 22:06
    Justine - Did Dr. de Grey or others discuss the use of the drug Rapamycin as an anti-aging protocol? There are doctors now who do so.
    • JU
      Justine U. | Real Vision
      2 November 2019 @ 18:31
      I didn’t specifically talk to Aubrey about rapamycin, we more generally talked about the human studies that were making the most progress [1]. I did however talk to Dr. Matt Kaeberlein at the University of Washington— his lab is running The Dog Aging Project [2], where they are testing the effects of rapamycin on our furry friends. Just a quick background on rapamycin for those who are unfamiliar with it: Rapamycin is an immune modulator and is given to patients receive organ transplants. The drug is produced by a soil bacterium found on Easter Island (and named after the native name for the island, Rapa Nui). The Buck Institute (one of the places we visit in the video) has done a lot of testing on rapamycin—they found that the drug can block a lot of the inflammatory secretions of senescent cells [3]. While rapamycin seems to be more effective in terms of life-extension benefits than metformin (see my metformin comment below), it also has many more side-effects: increased risk of type 2 diabetes, increased levels of cholesterol, and because it suppresses the immune system, it can make people more vulnerable to infections. So Dr. Kaeberlein wasn't recommending it for wide-spread human consumption just yet, but he mentioned he hopes the rapamycin study in dogs will raise awareness of the drug, and will eventually lead to more research on the drug’s anti-aging effects in humans. For anyone interested in learning more about rapamycin, I suggest reading about mTOR (mammalian target of rapamycin). [1] https://www.lifespan.io/the-rejuvenation-roadmap/ [2] https://dogagingproject.org/ [3] https://www.ncbi.nlm.nih.gov/pubmed/26147250
  • ML
    M L.
    2 November 2019 @ 18:26
    Great documentary. Might be also worth checking Kaya Kalpa and other Ayurvedic methods.
  • DB
    David B.
    1 November 2019 @ 14:18
    What additional research, articles, etc are worth reading on the subject of aging? I am particularly interested in diet / fasting since drugs are as yet unavailable. Thanks RV and Justine!
    • IO
      Igor O.
      1 November 2019 @ 14:38
      David Sinclair on Joe Rogan podcast.
    • JU
      Justine U. | Real Vision
      2 November 2019 @ 16:30
      Just a few notes I have on fasting… there isn't as much money to be made by pharma companies from this research, so there hasn't been a huge amount of investment in the topic. There has been some research in the U.S. (I highly recommend checking out this paper by Dr. Longo [1]) as well as in Russia and Germany. If you go down this rabbit hole, here are some other tangents worth considering... Dr. Cynthia Kenyon found that editing a single gene of the worm C. elegans could increase its lifespan by six-fold. The gene, daf-2, is part of what's called a ‘nutrient-sensing’ network, which makes sure an organism gets enough nutrient to fuel its vital activities. [2] The worm with a mutant daf-2 gene builds faulty receptors that limit the amount of hormones-- insulin and growth factors-- that get into its cells. These mutant worms lived far longer. According to Dr. Kenyon, “what we think is that, under conditions of stress, the levels of these hormones drop -- for example, having limited food supply. And that, we think, is registered by the animal as a danger signal, a signal that things are not okay and that it should roll out its protective capacity.” That protective capacity means an organism’s cells have increased ability to protect and repair themselves, which is what researchers *think* contributes to a longer life. And it’s thought that the FOXO3A gene variant does something similar in humans. In one study, those who had inherited this gene variant not only lived longer, but had less incidence of cancer, cardiovascular disease and cognitive decline than the controls, and were physically stronger, despite being on average 11 years older [3] Similar studies finding were repeated in populations of Han Chinese, Ashkenazi Jews, Californians, Germans, Italians and Danes. All of the functions of FOXO are not fully understood, but it is known that they “act as key regulators of longevity downstream of insulin and insulin-like growth factor signaling” [4]. [1] https://www.ncbi.nlm.nih.gov/pubmed/18378900 [2] https://www.ted.com/talks/cynthia_kenyon_experiments_that_hint_of_longer_lives [3] https://www.ncbi.nlm.nih.gov/pubmed/18765803 [4] https://www.ncbi.nlm.nih.gov/pubmed/26643314
  • SS
    Steve S.
    2 November 2019 @ 10:59
    Its amazing, the effort, time and expense that goes in just making a 30 minute episode. Well done Justine and RV.
  • DJ
    D J.
    2 November 2019 @ 07:44
    Fantastic documentary, and well covered
  • PB
    Pieter B.
    2 November 2019 @ 07:11
    Fantastic work Justine!
  • WB
    William B.
    2 November 2019 @ 01:48
    What a wonderful way to solve our health care problems and a big part of our debt issues!
  • KD
    Ken D.
    2 November 2019 @ 00:56
    Justine, I am quite conversant with the literature in the anti-aging field and I would like to commend you on the terrific job that you did in your presentation.
  • SS
    Steven S.
    1 November 2019 @ 18:22
    I conduct research in medical sciences and, in my opinion, this is an excellent piece, Justine. It presents some of the key aspects of longevity research: understanding the mechanisms underlying senescence promises to impact virtually all chronic diseases, shifting the foci of federal agencies (i.e., NIH) to fund these types of studies makes a lot of sense (some of that is going on currently and the NIA supports a large number of these studies), and efficacious therapeutic interventions are starting to arise which will offer many investment opportunities in the future (most of this is still quite far in the future). ...and to comment on the fasting discussion, yes, there is decent evidence for various types of fasting in humans to produce beneficial effects on metabolic function, systemic inflammation, and age-related biomarkers. Different fasting schemes (caloric restriction vs. short-term intermittent fasting vs. long-term fasting) appear to produce these effects through different mechanisms. Again, this work is in its infancy. Also, the DNA methylation profiling tests give you some idea about biological age, but they are far from perfect. DNA methylation patterns are tissue-specific. In a saliva sample, you're only interrogating methylation profiles of leukocytes and epithelial cells while ignoring all other cell types in your body. Keep up the great work, Justine.
    • RP
      Raoul P. | Founder
      1 November 2019 @ 23:39
      This is why I love Real Vision. Thank you Steven.
  • RP
    Raoul P. | Founder
    1 November 2019 @ 23:37
    Wow. Real Vision is growing up in front of our eyes. This is world class documentary content. I'm a rather proud father...!
  • EB
    Eric B.
    1 November 2019 @ 15:51
    Has the age test you took been released to the public yet?
    • JU
      Justine U. | Real Vision
      1 November 2019 @ 20:53
      The specific test I took in the video hasn't been released publicly yet (I believe it will be available in a few weeks). There are other ways of testing bioage-- some researchers I met use the website http://aging.ai/ (free to use, all you need is your blood marker information, although this does not give you any information about your epigenetics). I know some people who have used other testing kits like MyDNAge or BioViva. Depending on the sample you take (blood, urine, saliva, tissue) you may get a different age, as your skin tissue may be a different "age" than your liver, which may age at a different pace from your brain. A lot of this testing is based on Dr. Steve Horvath's work (Dr. Morgan Levine, who we talk to in the video, was one of his postdocs). The Horvath clock is able to estimate a person's age within 3.6 years on average, but certain cell types give better results-- saliva gave a prediction to within 2.7 years, some white blood cells to within 1.9 years, and brain cells to within 1.5 years.
  • DR
    David R.
    1 November 2019 @ 16:08
    Well done. Great documentary. Lots of stunning B-roll transitions. Thank you for this concise yet indepth discussion. Healthcare is so complicated i wonder who the winners and losers are in a macro view.
  • MC
    Minum C.
    1 November 2019 @ 15:45
    Excellent work! And awesome news from the man with the impressive beard. Sex, drugs, and rock 'n roll in perpetuity sounds good to me.
  • IO
    Igor O.
    1 November 2019 @ 14:13
    This subject is very welcome. As said in the video we are at the cusp and there will be opportunities.
    • IO
      Igor O.
      1 November 2019 @ 14:18
      .. that's way worst.. That's all Oreo cookies you eating Justin. We'll see consumer ready antiaging product at some point. Untill then low carb diet and exercise best bet.
  • SD
    Steven D.
    1 November 2019 @ 12:01
    Great job Justine ! Incredible to think what the future might hold.
  • RA
    Ralph A.
    1 November 2019 @ 11:45
    Exciting but R.I.P. social security. We will be so broke as a country